Alpha-Lipoic Acid

An Energetic Antioxidant

Alpha-lipoic acid is an important part of the process that turns sugar into energy in our bodies. Supplements of alpha-lipoic acid can lead to increases in available energy. Alpha-lipoic acid is also a useful and unique antioxidant, which, in addition to providing its own benefits, also is key to restoring and recycling other antioxidants, such as vitamin C, E and glutathione.

A "Perfect Antioxidant"
Alpha-lipoic acid meets most of the criteria to be classified as the "master" antioxidant. Its unique chemical structure gives it a wide range of actions. Alpha-lipoic acid is readily "reduced" to dihydrolipoic acid (DHLA) and DHLA can also be readily restored to alpha-lipoic acid. These two chemicals function together in very complex enzymatic processes, as well as helping regenerate other antioxidants. As a "perfect" antioxidant, alpha-lipoic acid (and DHLA) has beneficial interactions with other antioxidants. For example: recycling vitamin C, which in turn recycles vitamin E: reducing oxidized glutathione, which also recycles vitamin E, etc. Alpha-lipoic acid may have beneficial effects in inhibiting HIV-1 or controlling inflammation-regulating genes; these interactions are very complex, however, and require much further research.

Protection Against Diabetes
Alpha-lipoic acid may play a role in the protection against Type 1 diabetes and as a tool in mitigating the symptoms of this disease. Studies show that alpha-lipoic acid given intra-peritoneally for 10 days before and after a diabetes accelerator halved the number of non-obese, diabetes-prone mice who contracted Type 1 diabetes. Alpha-lipoic acid levels are known to be low in diabetic animals. This may interfere with the utilization of glucose in the glycolytic cycle, so supplementation of alpha-lipoic acid may help reduce the problem. Alpha-lipoic acid therapy for the pain from diabetic polyneuropathy (300 to 600 mg per day) has been approved in Germany as a result of clinical studies. And finally, because DHLA recycles vitamin C, alpha-lipoic acid can protect against cataracts caused by high blood sugar blocking replacement of vitamin C.

Radiation Injury
Radiation injury causes a profusion of free radicals. Twenty-eight days of alpha-lipoic acid therapy in children living in Chernobyl-poisoned areas reduced blood peroxidation to levels seen in non-poisoned children. Alpha-lipoic acid, with vitamin E, reduced it below normal levels: vitamin E alone was ineffective.

Suggested Use
Based on studies, 450 to 500 mg per day may be a safe and effective oral intake level for an adult weighing less than 120 pounds, and 600 to 700 mg for and adult weighing about 150 pounds, to delay the onset of diabetes. 200 to 600 mg per day appears to be a safe and effective oral intake level to reduce pain in diabetic neuropathy. Of course, instructions of caution should be included on labels and literature, and children, teenagers and pregnant women should avoid supplementation with alpha-lipoic acid unless under medical supervision.
Alpha-lipoic acid is a powerful nutrient for added energy and antioxidant protection.

This statement has not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, cure or prevent any disease.

This statement has not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, cure or prevent any disease.

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