SAM-e:
SAM-e is an important physiological agent formed in the body by combining the essential amino acid methionine with adenosyl-triphosphate (ATP). It is involved in over 40 biochemical reactions in the body. SAM-e functions closely with folic acid and vitamin B12 in methylation reactions- the process of adding a single carbon unit (a methyl group) to another molecule. It is many times more effective in transferring methyl groups than other methyl donors. Methylation reactions are critical in the manufacture of many body components, especially brain chemicals, and in detoxification reactions. The New York Times called SAM-e "a gentle remedy" and "a rival of Prozac". According to evidence documenting SAM-e's anti-depressant abilities SAM-e is an even better antidepressant that St. John's wort. In double-blind clinical studies between 1973 and 1987, SAM-e was proven superior to tested placebo.
Among those typically deficient in tissue levels of SAM-e are the elderly and patients suffering from osteoarthritis, depression, and various liver disorders. A deficiency of methionine, vitamin B12, or folic acid can result in this decreased SAM-e synthesis. However, high supplemental doses of methionine neither increase associated levels of SAM-e, nor provide equivalent pharmacological activity. They are also associated with some degree of toxicity. As of this writing, supplementation with SAM-e appears to safely and effectively treat these conditions. SAM-e is also used in the treatment of fibromyalgia and migraine headaches.

References:
Natural Alternatives to Prozac. Murray, Michael T.

This statement has not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, cure or prevent any disease.

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